EasyScript PlusTM Reverse Transcriptase is a novel recombinant reverse transcriptase that exhibits much higher efficiency in the first strand cDNA synthesis from RNA templates with secondary structures and high GC contents. The EasyScript PlusTM Reverse Transcriptase is engineered to work under high temperatures (50°C-55°C), which can further facilitate to resolve the secondary structures and high GC problems of RNA. Due to this feature, full-length cDNA can be synthesized from RNA templates that are up to 15 kb.